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Biological Contaminants of Emerging Concern

BioCEC

BioCEC Home
PDF – Full Document
About ITRC
Navigating this Website
Introduction
1. Introduction
2. Background
3. BioCEC Guidance Sections
4. Case Study: Effects of Hurricane Helene on Western North Carolina
Process Guide
1. Identification of BioCEC
2. Actions to Take
Conceptual Exposure Model
1. Introduction
2. Building a Conceptual Exposure Model Using the Epidemiologic Triangle
3. Using a Conceptual Exposure Model
4. Conceptual Exposure Model Examples
5. Case Study: Using a Conceptual Exposure Model to Address a 2018 E. coli Outbreak Linked to Romaine Lettuce
Key Variables
1. Introduction
2. The Epidemiological Triangle
3. Considerations for Assessing Risks from BioCEC
4. Approaches to BioCEC Prioritization Strategies
5. Tools for Prioritization
6. Limitations and Knowledge Gap
Analytical Methods
Analytical Methods
1. Description of Analytical Methods
2. Microscopy
3. Culture-Based Methods
4. Flow Cytometry
5. Matrix-Assisted Laser Desorption Ionization Time-of-Flight (MALDI-TOF) Mass Spectrometry (MS)
6. Polymerase Chain Reaction (PCR)
7. Genomics
8. Fluorescence In Situ Hybridization (FISH)
9. Microbial Fingerprinting Methods
10. Isothermal Amplification Approaches
Monitoring Programs / Resource Hub
1. Introduction
2. Methods for Consolidating the Table of Resources and Current Monitoring Methods
3. Overall Findings from the Systematic Review of BioCEC Programs
4. Opportunities and Challenges to Leveraging Existing Programs to Improve BioCEC Monitoring
Case Studies
1. Case Study: Blastomycosis Outbreak
2. Case Study: 2018 Escherichia coli Outbreak Linked to Romaine Lettuce
3. Case Study: Quantitative Microbial Risk Assessment (QMRA)
References
Glossary
Acronyms
Acknowledgments

 

Biological Contaminants of Emerging Concern
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Permission is granted to refer to or quote from this publication with the customary acknowledgment of the source. The suggested citation for this document is as follows:

ITRC (Interstate Technology & Regulatory Council). October 2025 Biological Contaminants of Emerging Concern (BioCEC). Washington, D.C.: Interstate Technology & Regulatory Council, CEC Team. https://cec-bio.itrcweb.org/.

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