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Biological Contaminants of Emerging Concern

BioCEC

BioCEC Home
PDF – Full Document
About ITRC
Navigating this Website
Introduction
1. Introduction
2. Background
3. BioCEC Guidance Sections
4. Case Study: Effects of Hurricane Helene on Western North Carolina
Process Guide
1. Identification of BioCEC
2. Actions to Take
Conceptual Exposure Model
1. Introduction
2. Building a Conceptual Exposure Model Using the Epidemiologic Triangle
3. Using a Conceptual Exposure Model
4. Conceptual Exposure Model Examples
5. Case Study: Using a Conceptual Exposure Model to Address a 2018 E. coli Outbreak Linked to Romaine Lettuce
Key Variables
1. Introduction
2. The Epidemiological Triangle
3. Considerations for Assessing Risks from BioCEC
4. Approaches to BioCEC Prioritization Strategies
5. Tools for Prioritization
6. Limitations and Knowledge Gap
Analytical Methods
Analytical Methods
1. Description of Analytical Methods
2. Microscopy
3. Culture-Based Methods
4. Flow Cytometry
5. Matrix-Assisted Laser Desorption Ionization Time-of-Flight (MALDI-TOF) Mass Spectrometry (MS)
6. Polymerase Chain Reaction (PCR)
7. Genomics
8. Fluorescence In Situ Hybridization (FISH)
9. Microbial Fingerprinting Methods
10. Isothermal Amplification Approaches
Monitoring Programs / Resource Hub
1. Introduction
2. Methods for Consolidating the Table of Resources and Current Monitoring Methods
3. Overall Findings from the Systematic Review of BioCEC Programs
4. Opportunities and Challenges to Leveraging Existing Programs to Improve BioCEC Monitoring
Case Studies
1. Case Study: Blastomycosis Outbreak
2. Case Study: 2018 Escherichia coli Outbreak Linked to Romaine Lettuce
3. Case Study: Quantitative Microbial Risk Assessment (QMRA)
References
Glossary
Acronyms
Acknowledgments

 

Biological Contaminants of Emerging Concern
HOME

Disease outbreaks in recent years have expanded public appreciation for linkage between an emerging environmental hazard and health outcomes. Oftentimes, there is not sufficient information to gauge health risk from emerging biological contaminants in the environment nor sufficient collaboration and communication between public health and environmental sectors to coordinate a response. Building a bridge between the expertise of environmental and public health sectors would help to fill this gap. 

This guidance document about biological contaminants of emerging concern (BioCEC) is intended for public health and environmental professionals and is rooted in the “One Health” framework. It aims to broaden and deepen technical knowledge and expedite quality regulatory decision-making while protecting human health and the environment. It builds upon the Contaminants of Emerging Concern (CEC) Framework that was published in December 2023 and is meant to provide guidance for states to identify and evaluate the broad range of contaminants and pathogens covered by the term BioCEC.

BioCEC are diverse, and the risks they pose are varied; therefore, it is important to note that this guidance is not comprehensive and will not identify specific risks. This guidance can, however, aid entities as they assess the risk for their unique circumstances. The scope of this guidance is driven in part by the ITRC team’s capacity and the expertise of the team members/volunteers.

⇐ ONLINE DOCUMENT: On this web page, use the Table of Contents shown in the left-hand navigation column to select a specific section of interest.

  • Introduction

  • Process Guide

  • Conceptual Exposure Models (CEMs)

  • Key Variables

  • Analytical Methods

  • Monitoring Programs / Resource Hub

  • Case Studies

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Bio CEC

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